abstract：:Few studies have been conducted examining cytokines in cerebrospinal fluid of patients compared to healthy volunteers. The goals of this study were: 1) to report original data detailing cytokine levels in the cerebrospinal fluid (CSF) of 10 patients with a schizophrenia spectrum disorder (SSD) diagnosis and 10 healthy...

journal_title：Schizophrenia research

authors： Gallego JA,Blanco EA,Husain-Krautter S,Madeline Fagen E,Moreno-Merino P,Del Ojo-Jiménez JA,Ahmed A,Rothstein TL,Lencz T,Malhotra AK

更新日期：2018-12-01 00:00:00

abstract：:Schizophrenia is modelled as a neurodevelopmental disease with high heritability. However, established markers like cortical thickness and grey matter volume are heavily influenced by post-onset changes and thus provide limited possibility of accessing early pathologies. Gyrification on the other side is assumed to be...

journal_title：Schizophrenia research

authors： Spalthoff R,Gaser C,Nenadić I

更新日期：2018-12-01 00:00:00

abstract：:The goal of this study was to determine if family burden experienced by the families of individuals with a recent-onset of schizophrenia is associated with whether the individual is able to work or attend school during the first year of treatment. Forty-one participants with a recent first episode of schizophrenia and...

journal_title：Schizophrenia research

authors： DeTore NR,Ventura J,Subotnik KL,Nuechterlein KH

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Higher liability to psychosis is associated with low self-esteem and increased sensitivity to social stress. Recently, we reported a positive relation between liability to psychosis and affective and psychotic responses to social stress. This study investigated how self-esteem moderates paranoia, peak subjec...

journal_title：Schizophrenia research

authors： Jongeneel A,Pot-Kolder R,Counotte J,van der Gaag M,Veling W

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Suicide is one of the leading causes of death in young individuals. Timely and adequate identification of individuals with suicidal ideation could prevent from suicidal behavior. Psychotic experiences (PE) have been shown to increase levels of suicidal ideation (SI) in the general population. Therefore, deta...

journal_title：Schizophrenia research

authors： Núñez D,Fresno A,van Borkulo CD,Courtet P,Arias V,Garrido V,Wigman JTW

更新日期：2018-11-01 00:00:00

abstract：:Increased rates of comorbid physical illness have been commonly reported in patients with schizophrenia. However, there are fewer data on dental disease in these patients. We systematically evaluated existing data on the oral health survey of schizophrenia patients through meta-analysis. Using the available databases,...

journal_title：Schizophrenia research

authors： Yang M,Chen P,He MX,Lu M,Wang HM,Soares JC,Zhang XY

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Neurocognitive deficits have been well documented in patients with schizophrenia. Research has shown that a significant proportion of patients with schizophrenia have co-morbid obsessive-compulsive symptoms/disorder (OCS/OCD). However, the impact of OCS/OCD on various neurocognitive domains in patients with ...

journal_title：Schizophrenia research

authors： Sahoo S,Grover S,Nehra R

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Cognitive remediation therapy (CRT) has shown significant improvement in cognition in schizophrenia. However, effect sizes of CRT have been reported to be modest raising the issue how to augment the effects of CRT on neurocognition and social cognition. Our aim was to examine whether the addition of computer...

journal_title：Schizophrenia research

authors： Lindenmayer JP,Khan A,McGurk SR,Kulsa MKC,Ljuri I,Ozog V,Fregenti S,Capodilupo G,Buccellato K,Thanju A,Goldring A,Parak M,Parker B

更新日期：2018-11-01 00:00:00

abstract：:Theory of mind (ToM) is the ability to understand mental states of others and it is crucial for building sensitivity to other persons or events. Measuring ToM is important for understanding and rehabilitating social cognitive impairments in persons with schizophrenia. The Social Attribution Task-Multiple Choice (SAT-M...

journal_title：Schizophrenia research

authors： Lee HS,Corbera S,Poltorak A,Park K,Assaf M,Bell MD,Wexler BE,Cho YI,Jung S,Brocke S,Choi KH

更新日期：2018-11-01 00:00:00

abstract：:The study of the mechanisms involved in cognition is of paramount importance for the understanding of the neurobiological substrates in psychiatric disorders. Hence, this research is aimed at exploring the brain network dynamics during a cognitive task. Specifically, we analyze the predictive capability of the pre-sti...

journal_title：Schizophrenia research

authors： Gomez-Pilar J,Poza J,Gómez C,Northoff G,Lubeiro A,Cea-Cañas BB,Molina V,Hornero R

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:While "dual diagnosis" involving both psychiatric and substance use disorders has long been a focus of schizophrenia research, recent studies have advocated for a shift of focus to multimorbidity, addressing comorbidity from both additional psychiatric disorders and substance use disorders. We hypothesized th...

journal_title：Schizophrenia research

authors： Bhalla IP,Stefanovics EA,Rosenheck RA

更新日期：2018-11-01 00:00:00

abstract：:Motor abnormalities (MAs) may be already evidenced long before the beginning of illness and are highly prevalent in psychosis. However, the extent to which the whole range of MAs are related to cognitive impairment in psychosis remains understudied. This study aimed to examine comparatively the relationships between t...

journal_title：Schizophrenia research

authors： Cuesta MJ,Moreno-Izco L,Ribeiro M,López-Ilundain JM,Lecumberri P,Cabada T,Lorente-Omeñaca R,Sánchez-Torres AM,Gómez MS,Peralta V

更新日期：2018-10-01 00:00:00

abstract：:Primary motor abnormalities (PMA), as found in patients with schizophrenia, are quantitatively and qualitatively distinct markers of motor system abnormalities. PMA have been often referred to phenomena that are present across schizophrenia-spectrum disorders. A dysfunction of frontoparietal and subcortical networks h...

journal_title：Schizophrenia research

authors： Hirjak D,Kubera KM,Thomann PA,Wolf RC

更新日期：2018-10-01 00:00:00

abstract：:Large studies investigating the psychosocial effects of lifestyle interventions in patients with a severe mental illness (SMI) are scarce, especially in residential patients. This large, randomized controlled, multicentre pragmatic trial assessed the psychosocial effects of a combined diet-and-exercise lifestyle inter...

journal_title：Schizophrenia research

authors： Stiekema APM,Looijmans A,van der Meer L,Bruggeman R,Schoevers RA,Corpeleijn E,Jörg F

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:In schizophrenic psychoses, the normal sexual dimorphism of the brain has been shown to be disrupted or even reversed. Little is known, however, at what time point in emerging psychosis this occurs. We have therefore examined, if these alterations are already present in the at-risk mental state (ARMS) for ps...

journal_title：Schizophrenia research

authors： Egloff L,Lenz C,Studerus E,Harrisberger F,Smieskova R,Schmidt A,Huber C,Simon A,Lang UE,Riecher-Rössler A,Borgwardt S

更新日期：2018-09-01 00:00:00

abstract：:This study tested the hypothesis that maternal exposure to terror attacks during pregnancy is associated with the risk of schizophrenia in the offspring. A population-based study was conducted of Israeli children born between 1975 and 1995 and that were registered in the Ministry of Interior and followed up in the Min...

journal_title：Schizophrenia research

authors： Weinstein Y,Levav I,Gelkopf M,Roe D,Yoffe R,Pugachova I,Levine SZ

更新日期：2018-09-01 00:00:00

abstract：:The use of clozapine requires monitoring the absolute neutrophil count because of the risk of agranulocytosis, but other potentially fatal adverse events associated with clozapine (specifically, myocarditis and cardiomyopathy) do not have mandatory procedures. We performed a systematic review of English-language artic...

journal_title：Schizophrenia research

authors： Knoph KN,Morgan RJ 3rd,Palmer BA,Schak KM,Owen AC,Leloux MR,Patel M,Leung JG

更新日期：2018-09-01 00:00:00

abstract：:A key predictor of whether or not an individual who hears voices (auditory verbal hallucinations; AVH) meets criteria for a psychiatric diagnosis is the level of negative content of the voices (e.g., threats, criticism, abuse). Yet the factors that contribute to negative voice-content are still not well understood. Th...

journal_title：Schizophrenia research

authors： Rosen C,McCarthy-Jones S,Jones N,Chase KA,Sharma RP

更新日期：2018-09-01 00:00:00

abstract：:Genetic and environmental models of neuropsychiatric disease have grown exponentially over the last 20years. One measure that is often used to evaluate the translational relevance of these models to human neuropsychiatric disease is prepulse inhibition of startle (PPI), an operational measure of sensorimotor gating. D...

journal_title：Schizophrenia research

authors： Khan A,Powell SB

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Clinical guidelines recommend maintenance treatment with antipsychotic medication for one to two years following remission of symptoms after a first episode of psychosis. However, recent research has suggested that this may not be indicated. Consistent predictors of outcome would be beneficial to guide clini...

journal_title：Schizophrenia research

authors： Bowtell M,Ratheesh A,McGorry P,Killackey E,O'Donoghue B

更新日期：2018-07-01 00:00:00

abstract：:Modified electroconvulsive therapy (MECT) has been widely applied to help treat schizophrenia patients who are treatment-resistant to pharmaceutical therapy. Although the technique is increasingly prevalent, the underlying neural mechanisms have not been well clarified. We conducted a longitudinal study to investigate...

journal_title：Schizophrenia research

authors： Huang H,Jiang Y,Xia M,Tang Y,Zhang T,Cui H,Wang J,Li Y,Xu L,Curtin A,Sheng J,Jia Y,Yao D,Li C,Luo C,Wang J

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:High rates of tobacco smoking and smoking cessation failure in schizophrenia may be related to prefrontal cortical dysfunction. Novel treatment options for tobacco use disorder are needed given the limited efficacy of current pharmacotherapies. Preliminary evidence suggests high-frequency repetitive transcra...

journal_title：Schizophrenia research

authors： Kozak K,Sharif-Razi M,Morozova M,Gaudette EV,Barr MS,Daskalakis ZJ,Blumberger DM,George TP

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated wit...

journal_title：Schizophrenia research

authors： Gjerde PB,Dieset I,Simonsen C,Hoseth EZ,Iversen T,Lagerberg TV,Lyngstad SH,Mørch RH,Skrede S,Andreassen OA,Melle I,Steen VM

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Acoustic phonetic methods are useful in examining some symptoms of schizophrenia; we used such methods to understand the underpinnings of aprosody. We hypothesized that, compared to controls and patients without clinically rated aprosody, patients with aprosody would exhibit reduced variability in: pitch (F0)...

journal_title：Schizophrenia research

authors： Compton MT,Lunden A,Cleary SD,Pauselli L,Alolayan Y,Halpern B,Broussard B,Crisafio A,Capulong L,Balducci PM,Bernardini F,Covington MA

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:People from culturally and linguistically diverse (CALD) backgrounds are over-represented in compulsory admissions to hospital but little is known about whether this also applies to community treatment orders (CTOs). AIMS:We investigated any differences between Australian- and foreign-born patients in the l...

journal_title：Schizophrenia research

authors： Kisely S,Xiao J

更新日期：2018-07-01 00:00:00

abstract：:Motivational deficits in patients with schizophrenia adversely affect various domains of daily living. This symptom in everyday life situations manifests in a complex behavioral pattern whose root cannot be simplified to an impaired reward-motivation scheme. This study aimed to identify impairment of the salience netw...

journal_title：Schizophrenia research

authors： Kim BH,Shin YB,Kyeong S,Lee SK,Kim JJ

更新日期：2018-07-01 00:00:00

abstract：:The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containin...

journal_title：Schizophrenia research

authors： Pawełczyk T,Piątkowska-Janko E,Bogorodzki P,Gębski P,Grancow-Grabka M,Trafalska E,Żurner N,Pawełczyk A

更新日期：2018-05-01 00:00:00

abstract：:Here, we used data from large genome-wide association studies to test the presence of causal relationships, conducting a Mendelian randomization analysis; and shared molecular mechanisms, calculating the genetic correlation, among schizophrenia, type 2 diabetes (T2D), and impaired glucose homeostasis. Although our Men...

journal_title：Schizophrenia research

authors： Polimanti R,Gelernter J,Stein DJ

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Patients with schizophrenia and comorbid drug use disorders (DUD) have a severe course of illness. Despite strong evidence that drug use can exacerbate psychotic symptoms, we have limited knowledge of how specific drugs may increase risk of schizophrenia readmission in this group. This study aimed to assess ...

journal_title：Schizophrenia research

authors： Rømer Thomsen K,Thylstrup B,Pedersen MM,Pedersen MU,Simonsen E,Hesse M

更新日期：2018-05-01 00:00:00

abstract：:Spectral entropy (SE) is a measurement from information theory field that provides an estimation of EEG regularity and may be useful as a summary of its spectral properties. Previous studies using small samples reported a deficit of EEG entropy modulation in schizophrenia during cognitive activity. The present study i...

journal_title：Schizophrenia research

authors： Molina V,Bachiller A,Gomez-Pilar J,Lubeiro A,Hornero R,Cea-Cañas B,Valcárcel C,Haidar MK,Poza J

更新日期：2018-05-01 00:00:00

abstract：:The dot pattern expectancy (DPX) task has been strongly recommended as a measure of goal maintenance, which is impaired in schizophrenia patients. The current event-related potential (ERP) study was designed mainly to identify the ERP component that could represent the goal maintenance process of the DPX task as index...

journal_title：Schizophrenia research

authors： Shen A,Zhao W,Han B,Zhang Q,Zhang Z,Chen X,Zhai J,Chen M,Du B,Deng X,Ji F,Wang C,Xiang YT,Wu H,Dong Q,Chen C,Li J

更新日期：2018-05-01 00:00:00

abstract：:Specialized First Episode Psychosis (FEP) services have been conceptualized in part around the issue of engagement. Creating treatment that is easier to access, with more frequent contacts, assertive outreach to clients between appointments, and an explicit youth-oriented culture could make services more attractive to...

journal_title：Schizophrenia research

authors： Kline E,Thomas L

更新日期：2018-05-01 00:00:00

abstract：:Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Ca...

journal_title：Schizophrenia research

authors： Norman RMG,MacDougall A,Manchanda R,Harricharan R

更新日期：2018-05-01 00:00:00

abstract：:Psychotic disorders are characterized by auditory verbal hallucinations (AVHs), and research has shown that AVHs are linked to deficits in working memory. Our understanding of AVHs across the psychosis continuum is limited. To date, little research has tested whether hallucination proneness (HP) is linked with abnorma...

journal_title：Schizophrenia research

authors： Gupta T,DeVylder JE,Auerbach RP,Schiffman J,Mittal VA

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Cannabis and cocaine are the most common illicit drugs for which people are treated in addiction services in Latin America. Much research has suggested that the use of cannabis increases the risk of schizophrenia; there is less evidence concerning cocaine. The aim of the present study was to establish the re...

journal_title：Schizophrenia research

authors： Libuy N,de Angel V,Ibáñez C,Murray RM,Mundt AP

更新日期：2018-04-01 00:00:00

abstract：:Although schizophrenia and developmental dyslexia are considered distinct disorders in terms of clinical presentation and functional outcome, they both involve disruption in the processes that support skilled reading, including language, auditory perception, visual perception, oculomotor control, and executive functio...

journal_title：Schizophrenia research

authors： Whitford V,O'Driscoll GA,Titone D

更新日期：2018-03-01 00:00:00

abstract：:Forensic patients with schizophrenia who had carried out a homicide scored higher on a measure of moral cognition (MFQ-30) than other violent patients. Neurocognitive impairment was associated with homicide by mediation via higher scores for in-group loyalty. ...

journal_title：Schizophrenia research

authors： O'Reilly K,O'Connell P,Corvin A,O'Sullivan D,Coyle C,Mullaney R,O'Flynn P,Grogan K,Richter M,Kennedy H

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic...

journal_title：Schizophrenia research

authors： Chiu PW,Lui SSY,Hung KSY,Chan RCK,Chan Q,Sham PC,Cheung EFC,Mak HKF

更新日期：2018-03-01 00:00:00

abstract：:repetitive thinking is often increased in various psychopathological conditions. However, evidence for its possible contribution to psychotic symptoms relies only on correlational analysis and has not been experimentally tested within the psychotic continuum. This research aims to examine whether repetitive thinking a...

journal_title：Schizophrenia research

authors： Ricarte JJ,Del Rey F,Ros L,Latorre JM,Berna F

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:The concept of dose equivalence of depot medication is important for many scientific and clinical purposes. METHODS:A systematic literature search on four second-generation antipsychotics available as long-acting injectable drugs and haloperidol was conducted. We used the minimum effective dose method which...

journal_title：Schizophrenia research

authors： Rothe PH,Heres S,Leucht S

更新日期：2018-03-01 00:00:00